Combine ground turkey, salt, garlic powder, onion powder, Italian seasoning, water, and breadcrumbs. Form into small meatballs.
Heat oil in a large pot or Dutch oven over medium heat. Brown the meatballs on all sides. Remove meatballs and set aside.
Add diced onion, carrots, and celery to the pot and cook until softened, about 5-7 minutes.
Pour in chicken broth and bring to a boil. Add orzo and cook according to package directions.
Return meatballs to the pot and simmer for 10-15 minutes, or until cooked through.
Stir in spinach and cook until wilted.
Season with salt and pepper to taste. Stir in lemon juice.
Serve immediately, garnished with grated Parmesan cheese.